← Research linesM1
M1 — Reproductive clock and delaying perimenopause
Discover what determines when perimenopause begins and select the first causal, measurable and manipulable node whose modification could delay the transition without shortening fertile function or displacing harm.
Subtopics
- 1.1Causal map of perimenopause onset — the `−2` bit is a σ threshold; the first licit node, if it exists, is not read in the classifier nor in primordial freeze
- 1.2Identity of the −2 σ generator — the bit is a persistence threshold; the biological candidate is origin jitter, not ρ nor buffer failure; ReSTAGE persistence is not estimable in any public `(L, FP, LP)` of 36–44 y
- 1.3ReSTAGE persistence: the Utah quantile describes a proxy, not the first passage; the clock adds no node; the ovarian index stays off
- 1.4ReSTAGE first passage under censoring