Laboratory reports

First ReSTAGE step under censoring

Reproductive clock and delaying perimenopause

ReSTAGE persistence: the Utah quantile describes a proxy, not the first passage; the clock adds no node; the ovarian index stays off

M1

Identity of the −2 σ generator — the bit is a persistence threshold; the biological candidate is origin jitter, not ρ nor buffer failure; ReSTAGE persistence is not estimable in any public `(L, FP, LP)` of 36–44 y

M1

Causal map of perimenopause onset — the `−2` bit is a σ threshold; the first licit node, if it exists, is not read in the classifier nor in primordial freeze

M1

Lifetime synthesis of the L1–L10 pathway — integrating the corpus does not produce a DAG; it produces a negative grammar and a classifier residual

Protocol design: validating senolytics in ethical observational perimenopause — the title names `do(senolysis)` on a graph that blood does not contain

Senolytics

Senolytics + NAD+ (NMN): proposed synergy — the title names a 2×2 that does not exist and a graph the ovary has not titled

Senolytics

Therapeutic window: when to intervene before senescent load is irreversible — the object is not a ceiling that a senolysis calendar can date

Senolytics

Fisetin as a natural senolytic: mechanism, bioaccessibility, and comparison with D+Q — what the evidence demonstrates, what is not ranked, and which hypotheses can be falsified

Senolytics

Dasatinib + quercetin and ovarian function: what the preclinical evidence demonstrates, what is missing in humans, and which hypotheses can be falsified

Senolytics

Senescent cells in the ovary: accumulation mechanism, SASP (senescence-associated secretory phenotype) and paracrine effect

Senolytics

Precursores de NAD+ en alimentos vs suplementos: equivalencia (o no) y correlacion con datos de food log de Lua

NAD+

NAD+ y mitocondria en celulas de granulosa: energia para la ovulacion y calidad ovocitaria

NAD+

CD38 as an NAD+ siphon: apigenin, quercetin, and reproductive longevity

NAD+

NMN versus NR: bioavailability, conversion to NAD+, and comparative clinical evidence in women's health and longevity

L9

SIRT6 and DNA repair in oocytes: the 2024–2026 frontier

L9

NAD+ and ovarian aging: SIRT1/SIRT3, compartments, and mitochondrial quality

L9

Hyperandrogenism in PCOS and the putative postmenopausal deficit: same axis, different dysfunctions

L8

Ovarian androgens: testosterone and androstenedione as estrogen precursors during the active cycle

L8

DHEA, cognitive function, muscle mass, and libido: real evidence versus marketing

L8

“Adrenopause” and menopause: two decoupled hormonal processes that converge—or do not—in tissue

L8

Peripheral aromatase: how adipose tissue converts DHEA-derived precursors into estrogens after menopause

L8

DHEA and DHEA-S: adrenal biosynthesis, life-course trajectory, and women's health/longevity

L8

Progesterone and cognitive function: neuroprotection versus neurodestruction by route of administration

L7

Urinary progesterone metabolites as non-invasive biomarkers: pregnanediol and pregnanetriol

L7

Progesterone deficit in perimenopause: why it appears to fall before estrogen and what consequences it may have

L7

Allopregnanolone as a neurosteroid: GABA-A modulation, anxiety, and insomnia in perimenopause

L7

5α-reductase and conversion to allopregnanolone: individual variability and neurological consequences

L7

Progesterone biosynthesis: from cholesterol to P4 through StAR, CYP11A1, and HSD3B

L7

GSTP1 and xenoestrogen detoxification: variants, electrophilic burden, and women's health

L6

VDR and ovarian function: from an “underestimated polymorphism” to a causal system of receptor, ligand, identity, and environment

L6

INSR/IRS1 Polymorphisms and Insulin Resistance in PCOS: Why the Same Diet Does Not Work Equally

L6

CYP1A1/CYP1B1, estrogen metabolism, and differential risk: why 2-OH versus 16-OH is not a “detoxification” axis

L6

L6-2 — MTHFR and folate: estrogen, homocysteine, and cardiovascular risk in menopause

L6

COMT and Estrogen Metabolism: Fast vs. Slow Methylators

Hormonal Nutrigenomics

Epigenetic reversibility of hormones: what can diet, exercise, fasting, and sleep actually change?

Epigenetics

Circulating miRNAs as non-invasive epigenetic biomarkers of hormonal age

Epigenetics

Xenoestrogens, BPA, and multigenerational epigenetic reprogramming

Epigenetics

Histones and aromatase in adipose tissue: the adipocyte as an endocrine organ

Epigenetics

ESR1/ESR2 methylation and functional estrogen resistance

Epigenetics

Epigenetic clock and ovarian age vs chronological age

Epigenetics

Circadian amplitude as a biomarker of perimenopausal transition

Chronobiology

Night Work, Rotating Shifts, and Sustained Hormonal Disruption

Chronobiology

Blue light, melatonin suppression, and the menstrual cycle

Chronobiology

Chrononutrition, nocturnal insulin, and hormonal peaks

Chronobiology

Melatonin-progesterone: the nocturnal signal that connects sleep, the luteal phase, and fertility

Chronobiology

Hashimoto as an Integrative Model of Hormonal Autoimmunity

Neuroendocrine + Immuno-endocrine + Microbiome

Iodine Deficiency in LATAM and Hormonal Consequences

Nutrigenomics + Neuroendocrine

CLOCK/BMAL1 and the clock inside the ovary

Chronobiology

Subclinical hypothyroidism × insulin resistance × PCOS: the thyroid-insulin-ovary triangle

Neuroendocrine + Metabolomics + Nutrigenomics

Thyroid autoimmunity (anti-TPO) and premature ovarian insufficiency/failure (POI/POF): association and mechanism

Neuroendocrine + Immuno-endocrine

Subclinical Hypothyroidism and the Luteal Phase: Reduced Progesterone, Anovulation, and Recurrent Miscarriage

Neuroendocrine / Emerging therapies

TSH as a global modulator of the menstrual cycle

Neuroendocrine

Adaptogens and the HPA-HPO axis: ashwagandha, rhodiola, mechanisms vs marketing

Neuroendocrine

Longitudinal HPA-axis phenotypes in female allostatic load

Applied AI / Neuroendocrine / Metabolomics

Adrenal allostasis in perimenopause: when the adrenal gland compensates, and when it fails

Neuroendocrine / Metabolomics

Progesterone vs cortisol: competition and co-signaling at the glucocorticoid receptor (GR) and luteal consequences

Neuroendocrine + Metabolomics + Microbiome (bridge)

Lua Labs Report — Ovarian CRH: the ovary produces its own stress hormone

Neuroendocrine — local intra-ovarian axis

GnRH and cortisol: how chronic stress desynchronizes the hormonal axis

Neuroendocrine

Gut-brain-ovary axis: complete circuit via the vagus nerve and bacterial metabolites (L1 closure)

Microbiome | Neuroendocrine

Specific prebiotics that modulate the estrobolome and progesterobolome

Microbiome · Nutrigenomics · Metabolomics

Fermented LATAM Foods and Hormonal Microbial Diversity

Microbiome

Dysbiosis as an accelerator of early menopause

Microbiome

Parabacteroides and progesterone: direct modulation beyond estrogen

Microbiome

Estrobolome: gut bacteria that metabolize estrogens via beta-glucuronidase

Microbiome